Plasma
Plasma is the fourth state of matter. It is a fascinating topic of research
worldwide with multiple surgical and medical applications (Plasma Medicine).
Plasma can be artificially produced either at very high temperature (i.e.: metal cutting), or at lower temperature with a partial gas ionization obtained through a difference of potential generated by specific electronic protocols.
More and more publications confirm that a low temperature plasma usage offers a number of very important medical advantages:
- it induces direct or indirect apoptosis (programmed death) of cancer cells (1,2);
- it stimulates the production of FGF-2 (Fibrin Growth Factor 2) with improved and faster tissue healing (3, 4);
- it increases the activity of some immune system cells (5,6).
Airplasma® technology works at low temperature and uses the surrounding atmosphere (air) as source of gas to generate plasma allowing significant benefits when applied in surgery.
Literature:
1) Clinical experience with cold plasma in the treatment of locally advanced head and neck cancer. (Hans-Robert Metelmann et al. – Clinical Plasma Medicine 9 – Feb 2018)
2) Plasma-activated medium (PAM) kills human cancerinitiating cells. (Ikeda JI et al. Pathol Int. 2018 Jan)
3) Endothelial Cell Proliferation is Enhanced by Low Dose Non-Thermal Plasma Through Fibroblast Growth Factor-2 Release (Sameed Kalghatgi et al. – Annals of Biomedical Engineering, Vol. 38, No. 3, March 2010)
4) Cold atmospheric plasma (CAP) activates angiogenesis-related molecules in skin keratinocytes, fibroblasts and endothelial cells and improves wound angiogenesis in an autocrine and paracrine mode. (Arndt S. et al. – J Dermatol Sci. 2018 Feb)
5) Immunogenic Potential Of Cold Atmospheric Plasma For The Treatment Of Pancreatic Cancer. (JintheVan Loenhout et al. – Clinical Plasma Medicine 9 – Feb 2018)
6) Potentiating anti-tumor immunity with physical plasma (Sander Bekeschus et al. Clinical Plasma Medicine, Volume 12, December 2018)